타이타늄 표면처리 방법이 흡착된 BSA의 용출 특성에 미치는 영향
Effects of Surface Modification Methods of Titanium on Release Characteristics of
김형용, 안지혜, 최해림, 박영준, 송호준,
소속 상세정보
김형용 ( Kim Hyung-Yong ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
안지혜 ( An Ji-Hae ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
최해림 ( Choi Hae-Rim ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
박영준 ( Park Young-Jun ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
송호준 ( Song Ho-June ) - 전남대학교 치의학전문대학원 치과재료학교실 및 치과재료연구소
KMID : 0362220110380040249
Abstract
In this study, titanium specimens with various surface conditions were fabricated using microarc oxidation (MAO) and hydrothermal (HT) treatment techniques and the effects of titanium surface characteristics on the release characteristics of bovine serum albumin (BSA) adsorbed on the surface were investigated. The MAO treated group (MAO), the MAO and HT treated groups using alkaline solution (MAO-HT), P-ion containing alkaline solution (MAO-HT-P), and Ca-ion containing alkaline solution (MAO-HT-Ca) were prepared. MAO treated specimens showed the smooth porous surface. However, hydrothermally treated specimens had newly formed nano-structures on porous surface, and their surface characteristics were changed by the chemical compositions of hydrothermal solutions. MAO and HT treated specimens had much
lower contact angle that is to have high hydrophilicity compared with MAO group. As a result of evaluating releasing characteristics and the final release quantities of BSA from MAO, MAO-HT, MAO-HT-P, and MAO-HT-Ca groups after immersing in BSA solution, MAO specimens had the highest value, and MAO-HT, MAO-HT-Ca showed similar values next, and MAO-HT-P specimens showed the lowest final release quantity. BSAs were released rapidly within 24 hours for MAO-HT-P and MAO-HT-Ca groups. However, MAO group showed a slower release characteristics of BSA compared with other groups.
키워드
Adsorption and release;Bovine serum albumin;Hydrothermal treatment; Microarc oxidation;Surface modification;Titanium
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